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Table of Contents | |
CHEMICALS WHICH CAUSE HYPOTHYROIDISM
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J Occup Environ Med
1997 Mar;39(3):258-60 |
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Evaluation of cyanide exposure and its effect on thyroid function of
workers in a cable industry.
Banerjee KK, Bishayee A, Marimuthu P
Department of Occupational Health, All India Institute of Hygiene and Public
Health, Calcutta, India.
A thyroid-hormone evaluation of workers dealing with cyanide compounds in an
electroplating process of a cable industry was carried out. Serum
thiocyanate (SCN) levels of 35 nonsmoking copper-ply employees were assayed
by a ferric-chloride color test. The mean SCN concentration of these
employees was 316 +/- 15 mumol/L, which was significantly (P < 0.01)
higher than that of control subjects (90.8 +/- 9.02 mumol/L). Serum
thyroxine (T4), triiodothyronine (T3), and thyroid-stimulating hormone (TSH)
concentrations of exposed workers were compared with those of 35 control
subjects. Cyanide exposure resulted in a decrease in T4 and T3
concentrations (P < 0.05) and an increase in TSH concentration (P <
0.05), compared with the control subjects. The serum T4 level was found
to be negatively correlated (r = -0.363, P < 0.05), whereas the TSH level
was positively correlated (r = 0.354, P < 0.05), with SCN concentration
in the exposed group. The study suggests that occupational cyanide
exposure in the industry impairs thyroid function.
PMID: 9093978, UI: 97247855
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