Bulletin Board
Archived Bulletin Board
About John
Latest Ideas
Symptoms
Tests and Drugs
Weight Loss Experiment
Hyperthyroidism
Hypothyroidism
Supplement List
Medical Science
Heredity
Other Diseases
Thyroid Physiology
Deeper Studies
Nutrients and Toxics
Hair Analysis
Book Reports
Glossary
Table of Contents | |
VITAMIN A
Vitamin A deficiency has been shown to increase T3 and this is
further increased by an additional deficiency of iodine. "In
the A- and A-I- groups, blood levels of retinol fell to one tenth of the control
mean and circulating concentrations of total and free T4 and T3 increased
significantly. This biochemical hyperthyroidism contrasted with the maintenance
of normal TSH plasma values, suggesting a generalized peripheral refractoriness
to thyroid hormones." vitamin
A deficiency causes hyperT.doc
The conversion of beta carotene into vitamin A is
driven by thyroid hormone. In hyperthyroidism, beta carotene is converted
rapidly into vitamin A (which I believe indicates a deficiency of A), while in
hypothyroidism, beta carotene conversion to A is markedly decreased, resulting
sometimes in a yellowish tint to the skin of a hypo who is consuming beta
carotene rich foods. JJ
- The following study shows that copper deficiency results in higher
liver concentrations of vitamin A (retinol) and lower blood levels of
vitamin A, suggesting that "a copper-deficient
diet may cause defective transport of vitamin A from liver to
blood."
-
- Title
Modification of vitamin A metabolism in rats fed a copper-deficient
diet.
Author
Rachman F; Conjat F; Carreau JP; Bleiberg-Daniel F; Amedee-Manesme O
Address
INSERM U 56, UniversitŽe Paris-Sud, H^opital d'Enfants, Bic^etre,
France.
Source
Int J Vitam Nutr Res, 57(3):247-52 1987
Abstract
The liver is the main storage site of vitamin A and copper.
Inverse relationships between copper and vitamin A liver
concentrations have been suggested. We have investigated the consequences of a copper-deficient
diet on liver and blood vitamin A storage in Wistar rats. Animals were fed
either a copper-deficient diet for 45 days from weaning, or an
identical diet containing adequate amounts of copper.
Concentrations of vitamin A were determined by isocratic high performance liquid
chromatography using UV detection. We have observed in the liver of the rats fed
a copper-deficient diet a significantly higher mean level of
retinyl esters (148 +/- 37 micrograms/g of liver) and retinol (3.3 +/- 1.4
micrograms/g of liver) compared to the mean concentration of the retinyl esters
(53 +/- 8.5 micrograms/g of liver) (p less than 0.01) and retinol (1.4 +/- 0.5
micrograms/g of liver) (p less than 0.01) in controls. Opposite results were
observed in the serum of the group fed a copper-deficient diet as
these rats had a significantly lower level of retinol (22 +/- 4 micrograms/100
ml) compared to the mean concentration in the controls (64 +/- 20 micrograms/100
ml) (p less than 0.01). These findings suggest that a copper-deficient
diet may cause defective transport of vitamin A from liver to blood. This
experimental model may be useful to further investigate unusual liver vitamin A
and copper concentrations observed in children during various
hepatobiliary diseases.
- Title
[Beta-carotene, vitamin A and carrier proteins in thyroid diseases]
Author
Aktuna D; Buchinger W; Langsteger W; Meister E; Sternad H; Lorenz O; Eber O
Address
Internen Abteilung, Krankenhauses der Barmherzigen Bršuder Graz-Eggenberg.
Source
Acta Med Austriaca, 20(1-2):17-20 1993
Abstract
The conversion of beta-carotene (provitamin A) to 2 molecules of vitamin A (retinol)
is accelerated by thyroxine and hyperthyroidism, respectively. The
characteristic yellow tint of the skin in hypothyroidism is due to hyper-beta-carotenemia.
Both in hyper- and hypothyroidism in a retinol deficiency has been observed in
literature. In a series of 36 patients (16 hyper-, 8 hypo-, and 12 euthyroid)
serum samples were analyzed for retinol and beta-carotene levels (high
pressure liquid chromatography) as well as retinol binding protein (radial
immune diffusion), prealbumin (nephelometry), and serum zinc
values (atomic absorption spectrometry) were established. The beta-carotene
serum level in the hypothyroid group (mean 1.1 microgram/ml) was significantly
higher (p < 0.05) in relation to euthyroid controls (0.6 microgram/ml), the
hyperthyroid group showed significantly lower values (0.3 microgram/ml). RBP
and prealbumin concentrations were significantly lower (p < 0.05) in
hyperthyroid as against eu- and hypothyroid patients. Surprisingly, in all 3
groups the retinol levels were not significantly different, although the
hyperthyroid group was slightly lower (0.6 microgram/ml) than the mean value
of 0.7 micrograms/ml in the other groups. A vitamin A and protein rich food,
customary in Central Europe, seems to rule out any vitamin A deficiency both
in hyper- and hypothyroidism. However, the beta-carotene values are
significantly higher in hypothyroidism, while in hyperthyroidism they were
lower. As intrahepatic zinc content plays an important role in
the synthesis of RBP and its secretion together with retinol, we also analyzed
this component: The serum zinc levels in hyperthyroid patients
were clearly higher (79.1 micrograms/dl) than in the hypothyroid group with 57
micrograms/dl (p < 0.05).
- The following study indicates that hyperthyroid cats have a 30% high
level of vitamin A (retinol) and a 30% lower level of vitamin E
(alpha-tocopherol) than normal cats.
-
Am J Vet Res 1993 Apr;54(4):563-9 |
|
Comparison of taurine, alpha-tocopherol, retinol,
selenium, and total triglycerides and cholesterol concentrations in cats
with cardiac disease and in healthy cats.
Fox PR, Trautwein EA, Hayes KC, Bond BR, Sisson DD, Moise
NS
Department of Medicine, Animal Medical Center, New York, NY 10021.
Epidemiologic relations were evaluated between plasma concentrations of
nutrients and cardiovascular diseases. A total of 220 cats were assessed:
144 cats with noninduced acquired heart disease and 76 clinically normal
cats. Plasma was assayed for taurine, alpha-tocopherol, selenium, retinol,
and total cholesterol and triglycerides concentrations. Cardiovascular
disease groups included dilated cardiomyopathy (n = 53), left ventricular
hypertrophy (n = 28), hyperthyroidism (n = 11), and uncertain classification
(n = 52). In cats with dilated cardiomyopathy, mean plasma taurine
concentration was the lowest of that in cats of any group, being only 38% of
the value in healthy cats; females had less than half the mean value of
males. Tocopherol concentration was 20% lower than normal, and retinol
concentration was 40% higher than normal. Total cholesterol concentration
was 36% lower than normal. Triglycerides concentration was higher in these
cats than in any other group--twice the value recorded in healthy cats and
67% higher than that in hyperthyroid cats. In cats with hypertrophic
cardiomyopathy, almost 15% had mean plasma taurine concentration < 30
mumol/L. Retinol concentration was 15% higher, and triglycerides
concentration was 54% higher than normal. Approximately 27% of hyperthyroid
cats had mildly decreased plasma taurine concentration. Hyperthyroid cats
had the lowest tocopherol and cholesterol values; both were at least 30%
lower than normal. Retinol concentration was 30% higher than normal.
Approximately 14% of cats with uncertain classification had mildly decreased
plasma taurine concentration. Plasma retinol and triglycerides
concentrations were higher than normal in 25 and 38% of these cats,
respectively.
-
Acta Med Austriaca 1983;10(2-3):71-3 |
t |
[Vitamin A and carotene in thyroid diseases].
[Article in German]
Smolle J, Wawschinek O, Hayn H, Eber O
From 190 goitrous patients (106 euthyroid, 53 hyperthyroid, 31 hypothyroid)
serum levels of vitamin A and carotene were obtained. The serum levels of
vitamin A were significantly decreased in both hyperthyroidism and
hypothyroidism, the serum levels of carotene in hypothyroidism only.
Remarkably, vitamin A levels almost never drop to subnormal values in
hyperthyroidism. There is evidence, that a sufficient dietary protein supply
enables the liver cell to produce enough amounts of retinol binding protein
and prealbumin to overcome the increased clearance observed in hyperthyroid
conditions.
-
Experientia Suppl 1983;44:264-97 |
|
Vitamin A-deficiency impairs the normal mannosylation,
conformation and iodination of thyroglobulin: a new etiological approach to
endemic goitre.
Ingenbleek Y
This study was undertaken in order to validate the hypothesis that vitamin
A-deficiency alters the structure of thyroglobulin (Tg). For that purpose,
four groups of 20 Sprague-Dawley rats were submitted during two months to
varying dietary conditions, namely a control diet (C+), a vitamin
A-deficient diet (A-), an iodine-deficient diet (I-) and a diet
characterized by the association of both deficiencies (A-I-). Both the
conventional parameters of thyroid function, the intracellular steps of Tg
glycosylation and iodination were analyzed. In the A- and A-I- groups, blood
levels of retinol fell to one tenth of the control mean and circulating
concentrations of total and free T4 and T3 increased significantly. This
biochemical hyperthyroidism contrasted with the maintenance of normal TSH
plasma values, suggesting a generalized peripheral refractoriness to thyroid
hormones. In both A- and A-I- groups, thyroid cytosol 3H-RPM (retinyl-phosphate-mannose)
and 3H-mannose incorporation into the core of the 12S-Tg and 19S-Tg species
were reduced by 40-50%. In contrast, cytosolic concentrations of 3H-DPM (dolichyl-phosphate-mannose)
rose, suggesting that the N-glycosylation pathways are affected in opposite
direction. The sedimentation coefficient in sucrose gradient of the purified
dimeric 125I-19S-Tg after guanidine 6M and dithiothreitol denaturation
showed that most of the A- Tg molecules were transformed into monomeric 12S
species, implying alterations of both noncovalent and covalent bonds.
Finally, the radiochromatogram of 125I-iodothyronines recovered after Tg
pronase digestion revealed a significant increase in the mono- (MIT) and
diiodothyronine (DIT) fractions in contrast with a significant decrease in
the T3 and T4 hormonal compounds. These findings are consistent with the
view that vitamin A-depletion impairs the endogenous RPM synthesis and,
therefore, the normal Tg 0-mannosylation. The growing peptide is
characterized by steric hindrance, leading to abnormal closure of disulphide
bonds, reduced MIT-DIT coupling reactions and depressed generation of
physiologically active thyroid hormones. pure iodine deficit (I-) induces no
effects on the above-mentioned glycosylation reactions, but iodine shortage
superimposed on preexisting vitamin A-deficit (A-I-) aggravates the Tg
dysmaturation
- The following study indicates that the benefits of vitamin A
supplementation on the hyperthyroid state has been "described for a
long time."
-
FEBS Lett 1992 Sep 28;310(2):101-5 |
|
Retinoic acid decreases retinoic acid and triiodothyronine
nuclear receptor expression in the liver of hyperthyroidic rats.
Higueret P, Pallet V, Coustaut M, Audouin I, Begueret J, Garcin H
Laboratoire de Nutrition, ISTAB, Universite Bordeaux I, Talence, France.
Retinoic acid (RA) and triiodothyronine (T3) exert many of their actions by
binding to specific nuclear receptors (respectively, RA receptor (RAR) and
T3) receptor (TR) belonging to a 'superfamily' of receptors. Some
heterologous regulation of these receptors has been shown, and in particular
regulation of the maximum binding capacity of TR by either retinol or RA.
Now, using hyperthyroidic rats as a model, the effect of RA on binding
capacity and on the mRNA levels of TR and RAR was investigated. The results
show that the benefit of vitamin A treatment for the hyperthyroidic state,
which has been described for a long time, could be the result of a down-heteroregulation
of TR by RA, the active metabolite of retinol.
|