|
Bulletin Board
Archived Bulletin Board
About John
Latest Ideas
Symptoms
Tests and Drugs
Weight Loss Experiment
Hyperthyroidism
Hypothyroidism
Supplement List
Medical Science
Heredity
Other Diseases
Thyroid Physiology
Deeper Studies
Nutrients and Toxics
Hair Analysis
Book Reports
Glossary
Table of Contents | |
VITAMIN B-2, RIBOFLAVIN
Thyroidal function: Facilitates copper metabolism and
therefore slows the thyroid. Supplementation of riboflavin without copper may
deplete copper and promote hyperthyroidism. A deficiency of riboflavin may be a
causative factor in Thyroid Eye Disease (TED).
Vitamin B-2 is the yellow colored B vitamin and is the one
responsible for making your urine yellow. If your urine is not yellow you may
not be getting enough B-2.
Deficiency symptoms: Itchy eyes and eyelids.
-
| Acta Psychiatr Scand 1992 May;85(5):360-3 |
|
Low thyroxine levels in female psychiatric inpatients
with riboflavin deficiency: implications for folate-dependent methylation.
Bell IR, Morrow FD, Read M, Berkes S, Perrone G
Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont.
Intermediates in the folate-dependent methylation pathways may play a role
in the etiology and treatment of such mental disorders as major depression.
These pathways include a step dependent on a riboflavin (B2)-derived
coenzyme, flavin adenine dinucleotide (FAD), which is reportedly sensitive
to thyroid status and to phenothiazine and tricyclic drug exposure. In a
sample of 52 male and female acute psychiatric inpatients, 17% (n = 9)
showed B2 deficiency (i.e., insufficient FAD activity) on a functional red
blood cell enzyme assay, but only one B2-deficient individual showed
deficiency in another B-complex vitamin (folate). All patients with B2
deficiency were women, who were also significantly younger than the rest of
the sample. The B2-deficient women had significantly lower thyroxine levels,
even when controlling for sex and covarying for age. B2-deficient patients
exhibited a nonsignificant trend toward more unipolar depression (44% vs
14%), but not toward bipolar or schizophrenic disorders. As in a previous
study, drug exposure did not show a relationship to riboflavin deficiency in
this sample. The findings suggest that B2 (FAD) activity may serve as a
sensitive marker of thyroxine status in certain female psychiatric
inpatients and that B2 deficiency may play an etiological role in defects of
the methylation pathways in a subset of mentally ill individuals.
|